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Refractoriness to bronchoconstriction following hyperventilation with cold dry air

1985; Wiley; Volume: 1; Issue: 2 Linguagem: Inglês

10.1002/ppul.1950010205

8755-6863

M Emilfork Soto, Robert P. Schnall, Louis I. Landau,

Thermal Regulation in Medicine

Abstract Fifteen subjects undertook repeated periods of hyperventilation of cold dry air and hyperventilation of warm humidified air followed by cold dry air. Hyperventilation of cold dry air induced a biphasic response with initial bronchodilatation followed by bronchoconstriction. However, exercise produced a greater rise in forced expiratory volume in 1 second (FEV 1 ) than hyperventilation alone. Hyperventilation of cold dry air resulted in a period of refractoriness to a second stress of the same type. Refractoriness induced by exercise or hyperventilation of cold dry air may be the result of refractoriness of the trigger site in the large airways.