Artigo Revisado por pares

Tryptophan Load Tests and Pyridoxal‐5‐phosphate Levels in Epileptic Children: II. Cryptogenic Epilepsy

1966; Wiley; Volume: 55; Issue: 4 Linguagem: Inglês

10.1111/j.1651-2227.1966.tb08808.x

ISSN

1651-2227

Autores

Bengt Hagberg, Arne Hamfelt, O Hansson,

Tópico(s)

Neuroscience and Neuropharmacology Research

Resumo

Acta PaediatricaVolume 55, Issue 4 p. 371-384 Tryptophan Load Tests and Pyridoxal-5-phosphate Levels in Epileptic Children: II. Cryptogenic Epilepsy BENGT HAGBERG, Corresponding Author BENGT HAGBERG Departments of Paediatrics and Clinical Chemistry, University Hospital, Uppsala, Sweden *Dept. of Clinical Chemistry 3 Dept. of Paediatrics. University Hospital Uppsala SwedenSearch for more papers by this authorARNE HAMFELT, Corresponding Author ARNE HAMFELT Departments of Paediatrics and Clinical Chemistry, University Hospital, Uppsala, Sweden With the technical assistance of Miss Ulla Netterdag. *Dept. of Clinical Chemistry 3 Dept. of Paediatrics. University Hospital Uppsala SwedenSearch for more papers by this authorOLLE HANSSON, Corresponding Author OLLE HANSSON Departments of Paediatrics and Clinical Chemistry, University Hospital, Uppsala, Sweden *Dept. of Clinical Chemistry 3 Dept. of Paediatrics. University Hospital Uppsala SwedenSearch for more papers by this author BENGT HAGBERG, Corresponding Author BENGT HAGBERG Departments of Paediatrics and Clinical Chemistry, University Hospital, Uppsala, Sweden *Dept. of Clinical Chemistry 3 Dept. of Paediatrics. University Hospital Uppsala SwedenSearch for more papers by this authorARNE HAMFELT, Corresponding Author ARNE HAMFELT Departments of Paediatrics and Clinical Chemistry, University Hospital, Uppsala, Sweden With the technical assistance of Miss Ulla Netterdag. *Dept. of Clinical Chemistry 3 Dept. of Paediatrics. University Hospital Uppsala SwedenSearch for more papers by this authorOLLE HANSSON, Corresponding Author OLLE HANSSON Departments of Paediatrics and Clinical Chemistry, University Hospital, Uppsala, Sweden *Dept. of Clinical Chemistry 3 Dept. of Paediatrics. University Hospital Uppsala SwedenSearch for more papers by this author First published: July 1966 https://doi.org/10.1111/j.1651-2227.1966.tb08808.xCitations: 26 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Benassi, C. A., Allegri, G., Benassi, P. and Rabassini, A.: Tryptophan metabolism in special pairs of twins. Clin Chim Acta. 9: 101, 1964. 2 Bessey, O. A., Adam, D. J. D., Bussey, D. R. and Hansen, A. E.: Vitamin B6 requirements in infants. Fed Proc, 13: 451, 1954. 3 Bessey, O. A., Adam, D. J. D. and Hansen, A. E.: Intake of vitamin B6 and infantile convulsions: A first approximation of requirements of pyridoxine in infants. Pediatrics, 20: 33, 1957. 4 Bower, B. D.: The tryptophan load test in the syndrome of infantile spasms with oligophrenia. Proc Roy Soc Med, 54: 540, 1961. 5 Boyland, E. and Williams, D. C.: The metabolism of tryptophan: 2. The metabolism of tryptophan in patients suffering from cancer of the bladder. Biochem J, 64: 578, 1956. 6 Calvario, M.: Carenza di piridossina ed epilessia. Acta vitamin, 1: 23, 1958. 7 Careddu, P.: Veränderungen des Tryptophanstoffwechsels bei den Blitz-Nick-Salaam-Krämpfen des Kindesalters. Helv Paediat Acta, 18: 398, 1963. 8 Christiaens, L., Briet, B. and Dehaene, PH.: Un cas familial de convulsions pyridoxino-sensibles. Pédiatrie, 17: 161, 1962. 9 Cochrane, W. A.: The syndrome of infantile spasms and progressive mental deterioration related to aminoacid and pyridoxine metabolism. Proceedings of IXth International Congress of Pediatrics, Montreal 1959, p. 115. 10 Coursin, D. B.: Convulsive seizures in infants with pyridoxine-deficient diet. JAMA 2: 406, 1954. 11 Coursin, D. B.: Present status of vitamin B6 metabolism. Amer J Clin Nutr, 9: 304, 1961. 12 Coursin, D. B.: Vitamin B6 deficiency in infants. A follow-up study. Amer J Dis Child, 90: 344, 1955. 13 Dahler, R. P.: Untersuchungen über den Tryptophanabbau und den Vitamin B6-stoffwechsel beim Neugeborenen und beim Säugling. Ann Paediat, 20: 346, 1963. 14 Dahler-Vollenweider, E. M.: Xanthuren-säureausscheidung nach Tryptophanbelastung bei Kindern. Ann Paediat, 200: 333, 1963. 15 Deneve, V. & Jongbloet, P.: Convulsies in de neonatale periode beinvloedbaar door pyridoxine. Maandschr Kindergeneesk, 29: 177, 1961. 16 Diamantstein, E. and Erhart, H.: Dünn-schichtchromatographische Trennung einiger Stoffwechselprodukte des Tryptophans. Hoppe-Seylers Zschr physiol Chem, 326: 131, 1961. 17 Eliot, J. W.: Occurrence of convulsions in infants as a possible manifestation of deficiency of vitamin B6. Report of the Tenth M & R Conf. Columbus, Ohio 1953, p. 53. 18 Ernsting, W. and Ferwerda, T. P.: De Behandeling van Epilepsie met Vitamine B6 (Pyridoxine, Adermine). Nederl T Geneesk, 95: 3643, 1951. 19 Fouts, P. J. and Lepkovsky, S.: A green pigment-producing compound in urine of pyridoxine-deficient dogs. Proc Soc Exp. Biol Med, 50: 221, 1942. 20 Fox, J. T. and Tullidge, G. M.: Pyridoxine (Vitamin B6) in epilepsy. A clinical trial. Lancet, II: 345, 1946. 21 Garty, R. Yonis, Z., Braham, J. and Steinitz, K.: Pyridoxine-dependent convulsions in an infant. Arch Dis Child, 37: 21, 1962. 22 Gehrmann, G.: Das Pyridoxin-Mangelsyndrom beim Menschen. Ergebn Inn Med Kinderheilk, 19: 274, 1963. 23 Hagberg, B., Hamfelt, A. and Hansson, O.: Epileptic children with disturbed tryptophan metabolism treated with vitamin B6.. Lancet, I: 145, 1964. 24 Hagberg, B., Hamfelt, A. and Hansson, O.: Tryptophan load tests and pyridoxal-5-phosphate levels in epileptic children. I. Non-progressive brain damage and degenerative brain disorders. Acta Pædiat Scand, 55: 363, 1966. 25 Hamfelt, A.: A method of determining pyridoxal phosphate in blood by decarboxylation of L-tyrosine-14C(U). Clin Chim Acta, 7: 746, 1962. 26 Hamfelt, A.: Unpublished observations. 27 Hellström, B. and Vassella, F.: Tryptophan metabolism in infantile spasms. Acta Pædiat Scand, 51: 665, 1962. 28 Hottinger, A. and Berger, H.: Vorläufige Bemerkungen zur Ausscheidung von Xanthurensäure und Kynurensäure nach Tryptophanbelastung. Internat Zschr Vitaminforsch, 34: 81, 1964. 29 Hottinger, A., Berger, H. and Krauthammer, W.: Klinische Beobachtungen zum Problem des Vitamin-B6-Metabolismus. Schweiz Med Wschr, 94: 221, 1964. 30 Hunt, A. D., Stokes, J., McCrory, W. W. and Stroud, H. H.: Pyridoxine dependency: Report of a case of intractable convulsions in an infant controlled by pyridoxine. Pediatrics, 13: 140, 1954. 31 Hunt, A. D.: Abnormally high pyridoxine requirement. Summary of evidence suggesting relation between this finding and clinical pyridoxine “deficiency”. Amer J Clin Nutr, 5: 561, 1957. 32 JÉROME, H., LeJeune, J. and Turpin, R.: Étude de l'excrétion urinaire de certains métabolites du tryptophan chez les enfants mongoliens. CR Acad Sci (Paris), 251: 474, 1960. 33 Jeune, M., Cotte, J., Hermier, M., Yasse, L. and Leriche, Mme: L'épreuve de charge au tryptophane comme moyen de détection des apyridoxinoses chez l'enfant. Pédiatrie, 14: 853, 1959. 34 Knapp, A.: Familiäre essentielle Tryptophanstoffwechselstörung. Klin Wschr, 38: 74, 1960. 35 Komrower, G. M., Wilson, V., Clamp, J. R. and Westall, R. G.: Hydroxykynureninuria: A case of abnormal tryptophan metabolism probably due to a deficiency of kynureninase. Arch Dis Childh, 39: 250, 1964. 36 DeLaey, P., Hooft, C., Timmermans, J. and Snoeck, J.: Biochemical aspects of the Hartnup disease. Ann Paediat, 202: 321, 1964. 37 Lepkovsky, S. and Nielsen, E.: A green pigment-producing compound in urine of pyridoxine-deficient rats. J Biol Chem, 144: 135, 1942. 38 Lepkovsky, S., Roboz, E. and Haagen-Smit, A. J.: Xanthurenic acid and its role in tryptophan metabolism of pyridoxine-deficient rats. J Biol Chem, 149: 195, 1943. 39 Livingston, S., Hsu, J. M. and Petersen, D. C.: Ineffectiveness of pyridoxine (vitamin B6) in the treatment of epilepsy. Pediatrics, 16: 250, 1955. 40 Marie, J., Hennequet, A., Lyon, G., Debris, P. and Le Balle, J.-C.: La pyridoxino-dépendance, maladie métabolique s'exprimant par des crises convulsives pyridoxino-sensibles (première observation familiale). Rev Neurol, 105: 406, 1961. 41 Marie, J., Hennequet, A., Lyon, G., Debris, P. and Le Balle, J.-C.: Les crises convulsives pyridoxino-sensibles du nouveau-né et du nourrisson. Ann Pédiat, 35: 197, 1959. 42 Marie, J., Hennequet, A., Lyon, G., Debris, P. and Le Balle, J.-C.: Sur un syndrome convulsif particulier du nouveau-né et du nourisson: “les crises convulsives pyridoxino-dépendantes”. Presse Med, 67: 568, 1959. 43 Marver, H. S.: Studies on tryptophan metabolism: 1. Urinary tryptophan metabolites in hypoplastic anemias and other hematologic disorders. J Lab Clin Med, 58: 425, 1961. 44 McCoy, E. E. and Chung, S. I.: The excretion of tryptophan metabolites following deoxypyridoxine administration in mongoloid and nonmongoloid patients. J Pediat, 64: 227, 1964. 45 Molony, C. J. and Parmelee, A. H.: Convulsions in young infants as a result of pyridoxine (vitamin B6) deficiency. JAMA, 154: 405, 1954. 46 Nordio, S., Segni, G. and Gandullia, E.: “Convulsioni piridossino-dipendenti.” Primo contributo della letteratura italiana. Minerva Pediat, 13: 925, 1961. 47 O'Brien, D. and Groshek, A.: The abnormality of tryptophane metabolism in children with mongolism. Arch Dis Child, 37: 17, 1962. 48 O'Brien, D. and Jensen, C. B.: Pyridoxine dependency in two mentally retarded subjects. Clin Sci, 24: 179, 1963. 49 Oka, M. and Leppänen, V. V. E.: Metabolism of tryptophan in diabetes mellitus. Acta Med Scand, 173: 361, 1963. 50 Piazza, M. and Tancredi, F.: Tryptophannicotinic acid metabolism in subjects recently or long since recovered from viral hepatitis. Nature, 197: 903, 1963. 51 Price, J. M.: Disorders of tryptophan metabolism. Univ Mich Med Bull, 24: 461, 1958. 52 Price, J. M., Brown, R. R. and Peters, H. A.: Tryptophan metabolism in porphyria, schizophrenia, and a variety of neurologie and psychiatric diseases. Neurology, 9: 456, 1959. 53 Schwarz-Tiene, E. and Careddu, P.: Alterazioni del metabolismo del triptofano nella fenilchetonuria, nell'ipsaritmia, nel mongolismo e in alcune cerebropatie infantili. Minerva Pediat, 14: 1471, 1962. 54 Scriver, C. R.: Vitamin B6 dependency and infantile convulsions. Pediatrics, 26: 62, 1960. 55 Scriver, C. R. and Hutchison, J. H.: The vitamin B6 deficiency syndrome in human infancy: biochemical and clinical observations. Pediatrics, 31: 240, 1963. 56 Snyderman, S. E., Carretero, R. and Holt, L. E.: Pyridoxine deficiency in the human being. Fed Proc, 9: 371, 1950. 57 Snyderman, S. E., Holt, L. E., Carretero, R. and Jacobs, K.: Pyridoxine deficiency in the human infant. Amer J Clin Nutr, 1: 200, 1953. 58 Sokoloff, L., Lassen, N. A., McKhann, G. M., Tower, D. B. and Albers, W.: Effects of pyridoxine withdrawal on cerebral circulation and metabolism in a pyridoxinedependent child. Nature, 183: 751, 1959. 59 Swaiman, K. F.: Vitamin B6 in seizures of infancy. Minnesota Med, 46: 525, 1963. 60 Tada, K. and Bessman, S. P.: Studies on tryptophan metabolism in oligophrenia phenylpyruvica. Pediat Japon, 3: 41, 1960. 61 Vasella, F., Hellström, B. and Wengle, B.: Urinary excretion of tryptophan metabolites in the healthy infant. Pediatrics, 30: 585, 1962. 62 Vila Badó, J., Samsó Díes, J. M. and Pado, N. L.: La vitamin B6 a dosis elevadas en el tratamiento de algunas encefalopatias infantiles. Ann Med Esp, 43: 316, 1957. 63 Wachstein, M. and Lobel, S.: The relation between tryptophan metabolism and vitamin B6 in various diseases as studied by paper chromatography. J Clin Pathol, 26: 910, 1956. 64 Waldinger, C.: Pyridoxine deficiency and pyridoxine dependency in infants and children. Postgrad Med, 35: 415, 1964. 65 Waldinger, C. and Berg, R. B.: Signs of pyridoxine dependency manifest at birth in siblings. Pediatrics, 32: 161, 1963. 66 Weller, H. and Fichtenbaum, M.: Der Tryptophanbelastungstest als Nachweis eines Vitamin B6-Mangels bei Arteriosclerose. Klin Wschr, 39: 1275, 1961. 67 Zunin, C. and Vallarino, G.: Le crisi convulsive sensibili alla piridossina. Presentazione di un caso. Minerva Pediat, 15: 975, 1963. Citing Literature Volume55, Issue4July 1966Pages 371-384 ReferencesRelatedInformation

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