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Evaluation of Current Methods for the Measurement of Serum Anti–Double‐Stranded DNA Antibodies

2007; Wiley; Volume: 1109; Issue: 1 Linguagem: Inglês

10.1196/annals.1398.045

1749-6632

Anna Ghirardello, Danilo Villalta, Gabriella Morozzi, Antonella Afeltra, Mauro Galeazzi, Roberto Gerli, Alessandro Mathieu, Pier Luigi Meroni, Paola Migliorini, Antonella Radice, Valeria Riccieri, Amelia Ruffatti, Gian Domenico Sebastiani, Anǵela Tincani, Andrea Doria,

Lymphoma Diagnosis and Treatment

Abstract : Autoantibodies to double‐stranded DNA (dsDNA) are, by definition, serological markers of systemic lupus erythematosus. However, the clinical value of anti‐dsDNA antibodies largely depends on the assay principle and analytical variables of the methods used to quantitate and immunologically characterize them. In the present article, an overview of current methods for anti‐dsDNA antibody detection is presented, together with a look at the future trends in technologies newly employed in this field.