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Circadian Rhythm of Synaptic Excitability in Rat And Monkey Central Nervous System

1977; American Association for the Advancement of Science; Volume: 197; Issue: 4298 Linguagem: Inglês

10.1126/science.194313

1095-9203

C. A. Barnes, B. L. McNaughton, Graham V. Goddard, R. M. Douglas, Robert E. Adamec,

Photoreceptor and optogenetics research

Synaptic responses in hippocampal granule cells to stimulation of their afferent fibers from the entorhinal cortex fluctuate with a 24-hour period. The phase of this cycle for rats and monkeys depends on whether the animal is naturally nocturnal or diurnal. In a rat blinded by enucleation, the rhythm persists but drifts out of phase with the rhythm of sighted controls.