Voltar
Revisão Acesso aberto Revisado por pares
BIBTEX RIS

TNF and MAP kinase signalling pathways

2014; Elsevier BV; Volume: 26; Issue: 3 Linguagem: Inglês

10.1016/j.smim.2014.02.009

ISSN

1096-3618

Autores

Guadalupe Sabio, Roger J. Davis,

Tópico(s)

interferon and immune responses

Resumo

The binding of tumour necrosis factor α (TNFα) to cell surface receptors engages multiple signal transduction pathways, including three groups of mitogen-activated protein (MAP) kinases: extracellular-signal-regulated kinases (ERKs); the cJun NH2-terminal kinases (JNKs); and the p38 MAP kinases. These MAP kinase signalling pathways induce a secondary response by increasing the expression of several inflammatory cytokines (including TNFα) that contribute to the biological activity of TNFα. MAP kinases therefore function both upstream and down-stream of signalling by TNFα receptors. Here we review mechanisms that mediate these actions of MAP kinases during the response to TNFα.

Referência(s)