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Synthesis of 3-(Substituted Methyl)-2-phenyl-4 H -1-benzothiopyran-4-ones

1984; Oxford University Press; Volume: 57; Issue: 8 Linguagem: Inglês

10.1246/bcsj.57.2323

1348-0634

Hiroyuki Nakazumi, Tamio Ueyama, H. SONODA, Teijiro Kitao,

Synthesis and Reactivity of Sulfur-Containing Compounds

Abstract Reaction of 2-phenyl-4H-1-benzothiopyran-4-ones and related compounds with chloromethyl methyl ether and fuming sulfuric acid gave mainly 3-chloromethyl compound, whereas chloromethylation of methoxy-substituted thioflavones took place at another position or gave tris(chloromethyl) compound. 3-(Chloromethyl)thioflavone could be easily converted into various 3-(substituted methyl)thioflavones which showed significant antimicrobial activity against Trichophytons.