Syntheses of two tyrosine-sulphate containing peptides. Leucosulfakinin (LSK)-II and cholecystokinin (CCK)-12, using the 0--(methylsulphinyl)benzyl serine for the selective sulphation of tyrosine
1992; Elsevier BV; Volume: 48; Issue: 41 Linguagem: Inglês
10.1016/s0040-4020(01)81989-x
ISSN1464-5416
AutoresShiroh Futaki, Takashi Taike, Tadashi Akita, Kouki Kitagawa,
Tópico(s)Receptor Mechanisms and Signaling
ResumoA novel approach for the synthesis of tyrosine sulphate [Tyr(SO3H)]-containing peptides was developed. In this approach, trifluoroacetic acid stable O-p-(methylsulphinyl)-benzyl group was used as a key protecting group for serine to achieve the selective sulphation of tyrosine.
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