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Synthesis and characterisation of a new polycyclic phenazine from 1,4-naphthoquinone

2011; Elsevier BV; Volume: 52; Issue: 18 Linguagem: Inglês

10.1016/j.tetlet.2011.03.006

1873-3581

Matuzalém J. da Silva, Maria do Carmo F. R. Pinto, Carlos A. de Simone, Janaína G. Soares, José Rui Machado Reys, José Dias de Souza Filho, William T. A. Harrison, C.E.M. Carvalho, Marília Oliveira Fonseca Goulart, Eufrânio N. da Silva Júnior, António Pinto,

Synthesis of Organic Compounds

Bioactive naphthoquinone-derived heterocyclic compounds have been prepared. Herein, we describe the semisynthesis of a new phenazine, through modified Hooker’s reaction, using lapachol as a precursor. This compound was characterised by 2D NMR spectroscopy methods and X-ray analysis.