Artigo Acesso aberto Revisado por pares

3D mapping of synaptic connections within "in silico" microcircuits of full compartmental neurons in extended networks on the example of VPM axons projecting into S1 of rats.

2009; Frontiers Media; Volume: 3; Linguagem: Inglês

10.3389/conf.neuro.11.2009.08.092

ISSN

1662-5196

Autores

Marcel Oberlaender, Vincent J. Dercksen, Stefan Lang, Moritz Helmstaedter, Bert Sakmann,

Tópico(s)

Neural dynamics and brain function

Resumo

Event Abstract Back to Event 3D mapping of synaptic connections within "in silico" microcircuits of full compartmental neurons in extended networks on the example of VPM axons projecting into S1 of rats. Marcel Oberlaender1*, Vincent J. Dercksen2, Stefan Lang3, Moritz Helmstaedter4 and Bert Sakmann5 1 Max Planck Institute for Neurobiology, Group Cortical Column in silico, Germany 2 Zuse Institute Berlin, Germany 3 IWR, Germany 4 MPI for Medical Research, Germany 5 MPI of Neurobiology, Germany Determination of the number and 3D distribution of synaptic connections for individual neuron populations is a key prerequisite to establish large full compartmental neuron network models. Recently described methods for determination of synaptic contact sites using channelrhodopsin-2 (ChR2) (Petreanu et al., 2009) or serial block-face scanning electron microscopy (SBFSEM) (Seung & Denk, Connectomics Project) are promising but not yet satisfying in mapping all synaptic connections for large functional units such as a cortical column. In contrast to these "direct" methods, the statistical approach described here focuses on mapping synaptic connections onto anatomically determined microcircuits in average neuronal networks. A "toolbox" will be described on the example of thalamocortical synapses from neurons originating in the ventral posterior medial (VPM) thalamic nucleus and projecting into the primary somatosensory cortex (S1) of rats. INCF-09-29-1 INCF-09-29-2 Conference: Neuroinformatics 2009, Pilsen, Czechia, 6 Sep - 8 Sep, 2009. Presentation Type: Poster Presentation Topic: Computational neuroscience Citation: Oberlaender M, Dercksen VJ, Lang S, Helmstaedter M and Sakmann B (2019). 3D mapping of synaptic connections within "in silico" microcircuits of full compartmental neurons in extended networks on the example of VPM axons projecting into S1 of rats.. Front. Neuroinform. Conference Abstract: Neuroinformatics 2009. doi: 10.3389/conf.neuro.11.2009.08.092 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 22 May 2009; Published Online: 09 May 2019. * Correspondence: Marcel Oberlaender, Max Planck Institute for Neurobiology, Group Cortical Column in silico, Munich, Germany, oberlaender@neuro.mpg.de Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Marcel Oberlaender Vincent J Dercksen Stefan Lang Moritz Helmstaedter Bert Sakmann Google Marcel Oberlaender Vincent J Dercksen Stefan Lang Moritz Helmstaedter Bert Sakmann Google Scholar Marcel Oberlaender Vincent J Dercksen Stefan Lang Moritz Helmstaedter Bert Sakmann PubMed Marcel Oberlaender Vincent J Dercksen Stefan Lang Moritz Helmstaedter Bert Sakmann Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.

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