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Assymetric reduction of ketones using LiAlH4 modified with chiral 1,2-aminodiols.txt

1981; Elsevier BV; Volume: 22; Issue: 28 Linguagem: Inglês

10.1016/s0040-4039(01)92952-1

1873-3581

J. D. Morrison, Edward R. Grandbois, Sachiko I. Howard, Gary R. Weisman,

Asymmetric Synthesis and Catalysis

Four chiral aminodiols from ring opening of (S)-propylene oxide and ethylene oxide wiht n-butylamine and (R) or (S)-α-methylbenzylamine were used to modify LiAlH4. Assymetric reduction of acetophenone and propiophenone gave the highest percent enantiomeric excess when the modifier was made from (S)-oxide and (S)-amine.