Revisão Revisado por pares

Coupling of folding and binding for unstructured proteins

2002; Elsevier BV; Volume: 12; Issue: 1 Linguagem: Inglês

10.1016/s0959-440x(02)00289-0

ISSN

1879-033X

Autores

H. Jane Dyson, Peter E. Wright,

Tópico(s)

Mass Spectrometry Techniques and Applications

Resumo

There are now numerous examples of proteins that are unstructured or only partially structured under physiological conditions and yet are nevertheless functional. Such proteins are especially prevalent in eukaryotes. In many cases, intrinsically disordered proteins adopt folded structures upon binding to their biological targets. Many new examples of coupled folding and binding events have been reported recently, providing new insights into mechanisms of molecular recognition.

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