HLA linked immune response to S and pre‐S2 gene products in hepatitis B vaccination
1989; Wiley; Volume: 33; Issue: 5 Linguagem: Inglês
10.1111/j.1399-0039.1989.tb01700.x
ISSN1399-0039
AutoresM.R. Marescot, Agata Budkowska, J Pillot, Patrice Debré,
Tópico(s)Immune Response and Inflammation
ResumoIn order to detect a possible HLA linked genetic control of human immune responses to hepatitis B virus, forty healthy adult persons of the same age typed for HLA‐A, ‐B and ‐DR antigens, were vaccinated against virus hepatitis B and sequentially tested for anti‐HBs and anti‐pre‐S2 antibodies. They received three injections of Hevac‐B Pasteur vaccine, the second 1 month and the third 3 months after the first. Following the third immunization, 38 individuals (95%) had a protective level of anti‐HBs antibodies and 17 (42.3%) had a positive level of anti‐pre‐S2 antibodies. HLA‐A11 antigen was significantly more frequent (pc = 0.007) among anti‐HBs high responders than low responders. In addition, anti‐HBs high responders were more frequently HLA‐DR1, and less frequently HLA‐DR4 and DR7 positive; corrected values, however, were not significant. Anti‐pre‐S2 high responders showed an apparent increase of HLA‐B7, B14 or DR3 antigens, when compared to low responders (pc not significant).
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