Distinct manifestations of human papillomaviruses in the vagina
1997; Wiley; Volume: 72; Issue: 3 Linguagem: Inglês
10.1002/(sici)1097-0215(19970729)72
ISSN1097-0215
AutoresMotoyasu Sugase, Toshihiko Matsukura,
Tópico(s)Endometrial and Cervical Cancer Treatments
ResumoInternational Journal of CancerVolume 72, Issue 3 p. 412-415 Human CancerFree Access Distinct manifestations of human papillomaviruses in the vagina Motoyasu Sugase, Motoyasu Sugase Department of Obstetrics and Gynecology, Nagano Red Cross Hospital, Nagano, JapanSearch for more papers by this authorToshihiko Matsukura, Corresponding Author Toshihiko Matsukura Laboratory of Tumor Viruses, Department of Virology II, National Institute of Health, Tokyo, JapanLaboratory of Tumor Viruses, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo 162, JapanSearch for more papers by this author Motoyasu Sugase, Motoyasu Sugase Department of Obstetrics and Gynecology, Nagano Red Cross Hospital, Nagano, JapanSearch for more papers by this authorToshihiko Matsukura, Corresponding Author Toshihiko Matsukura Laboratory of Tumor Viruses, Department of Virology II, National Institute of Health, Tokyo, JapanLaboratory of Tumor Viruses, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo 162, JapanSearch for more papers by this author First published: 06 December 1998 https://doi.org/10.1002/(SICI)1097-0215(19970729)72:3 3.0.CO;2-SCitations: 65AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract To clarify the pathogenic relationships between human papillomavirus (HPV) and vaginal intraepithelial neoplasia (VAIN), we examined 71 vaginal biopsy specimens by histopathology and immunohistochemistry and analyzed the presence of HPV DNA by blot hybridization at Tm − 40°C using an HPV 58 probe (PBM-58 method). We found 27 cases of VAIN in patients with previous hysterectomy or antecedent or concomitant cervical intraepithelial neoplasia (CIN) and 44 cases of VAIN in patients without any abnormal findings on the cervix and the vulva. Histopathologically, 53 of 71 cases were graded as VAIN I and 15 and 3 cases were VAIN II and III, respectively, while 59 cases showed positivity for HPV capsid antigen by immunohistochemistry. Using the PBM-58 method, all 71 VAIN cases harbored a single HPV type at more than 1,000 viral copies per cell. 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