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Formal analysis of protein sequences: I. Specific long-range constraints in pair associations of amino acids

1967; Elsevier BV; Volume: 17; Issue: 1 Linguagem: Inglês

10.1016/0022-5193(67)90025-2

1095-8541

A. Krzywicki, Piotr P. Słonimski,

Protein Structure and Dynamics

Abstract A thorough formal investigation of pair correlations between amino acids in various protein sequences is performed. To this end we apply a particularly sensitive method of statistical analysis. An evidence is given for the existence of correlations between amino acids separated, along the polypeptide chain, by 5 and 6 and by 28 and 29 peptide bonds. We discuss the chemical nature of these correlations and their possible relation to the three-dimensional structure of proteins.