Reagent-free determination of amikacin content in amikacin sulfate injections by FTIR derivative spectroscopy in a continuous flow system
2013; Elsevier BV; Volume: 4; Issue: 2 Linguagem: Inglês
10.1016/j.jpha.2013.08.001
ISSN2214-0883
AutoresFernando Ovalles, Máximo Gallignani, Marı́a del Rosario Brunetto, Rebeca Rondón, Carlos Ayala,
Tópico(s)Analytical Methods in Pharmaceuticals
ResumoThe quantitative estimation of amikacin (AMK) in AMK sulfate injection samples is reported using FTIR-derivative spectrometric method in a continuous flow system. Fourier transform of mid-IR spectra were recorded without any sample pretreatment. A good linear calibration (r>0.999, %RSD<2.0) in the range of 7.7-77.0 mg/mL was found. The results showed a good correlation with the manufacturer's and overall they all fell within acceptable limits of most pharmacopoeial monographs on AMK sulfate.
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