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Influences of hypercholesterolemia on red cell indices and erythrocyte sedimentation rate in elderly persons

2004; Elsevier BV; Volume: 341; Issue: 1-2 Linguagem: Inglês

10.1016/j.cccn.2003.11.013

1873-3492

Jong Weon Choi, Soo Hwan Pai,

Diabetes, Cardiovascular Risks, and Lipoproteins

We investigated whether hypercholesterolemia influenced the values of mean corpuscular volume (MCV) and erythrocyte sedimentation rate (ESR).A total of 463 nonanemic elderly persons were evaluated regarding red cell indices, ESR, and ESR-related parameters, such as fibrinogen, albumin, and C-reactive protein (CRP).There were no significant differences in MCV between elderly men with and without hypercholesterolemia (>/=240 mg/dl) nor between the subjects with a marked increase of serum cholesterol concentrations (>/=260 mg/dl) and with severely lowered cholesterol concentrations (<155 mg/dl). ESR in elderly men with hypercholesterolemia averaged 12.3+/-6.8 mm/h, which were significantly higher than in those without hypercholesterolemia (6.0+/-4.7 mm/h, p /=260 mg/dl versus those with serum cholesterol concentrations /=15.0 mm/h (248.9+/-43.5 mg/dl), compared to those with ESR<2.0 mm/h (199.5+/-31.7 mg/dl, p<0.01). Serum cholesterol concentrations showed no associations with red cell indices but correlated significantly with ESR in elderly men (r=0.24, p<0.01) and postmenopausal women (r=0.21, p<0.01).Hypercholesterolemia does not appear to influence MCV but significantly accelerates ESR, especially in elderly men.