Overexpression and clinical significance of carcinoembryonic antigen-related cell adhesion molecule 6 in colorectal cancer
2012; Elsevier BV; Volume: 415; Linguagem: Inglês
10.1016/j.cca.2012.09.003
ISSN1873-3492
AutoresKwang S. Kim, Jong‐Tae Kim, Seon‐Jin Lee, Min Ah Kang, In Seong Choe, Yun Hee Kang, Seon‐Young Kim, Young Il Yeom, Young‐Ha Lee, Joo Heon Kim, Kyo Hyun Kim, Chang Nam Kim, Jong Wan Kim, Myoung‐Soo Nam, Hee Gu Lee,
Tópico(s)Cancer Research and Treatments
ResumoCarcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) inhibits anoikis and affects the malignant phenotype of cancer cells. In this study, we analyzed CEACAM6 as a gene that is highly upregulated in colon cancer tissues, and examined the assertion that CEACAM6 might be a suitable candidate tumor marker for the diagnosis of colon cancer. CEACAM6 gene expression in human colon tissues was performed by tissue microarray and analyzed using RT-PCR (each of normal and tumor tissue, n = 40) and immunohistochemical and clinicopathological (colon cancer patients, n = 143) analyses. CEACAM6 transcriptional and translational levels were significantly upregulated in human tumor tissues compared to non-tumor regions, and clinicopathological analysis revealed a significant correlation between CEACAM6 protein expression and Dukes' stage (p < 0.001). High expression levels of CEACAM6 were significantly associated with lower overall survival (p < 0.001) and shorter recurrence-free survival (p < 0.001). We demonstrated that knockdown of CEACAM6 with CEACAM6-specific small interfering RNA in colorectal cancer cells attenuated invasivity (35%); conversely, the overexpression of CEACAM6 increased invasiveness. CEACAM6 is significantly upregulated in colon cancer tissues and is closely associated with poor prognosis, indicating that CEACAM6 might be used as a tumor biomarker and a potential therapeutic target for colon cancer.
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