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Osteopontin: Role in extracellular matrix deposition and myocardial remodeling post-MI

2009; Elsevier BV; Volume: 48; Issue: 3 Linguagem: Inglês

10.1016/j.yjmcc.2009.06.015

1095-8584

Mahipal Singh, Cerrone R. Foster, Suman Dalal, Krishna Singh,

Cardiac Fibrosis and Remodeling

Remodeling after myocardial infarction (MI) associates with left ventricular (LV) dilation, decreased cardiac function and increased mortality. The dynamic synthesis and breakdown of extracellular matrix (ECM) proteins play a significant role in myocardial remodeling post-MI. Expression of osteopontin (OPN) increases in the heart post-MI. Evidence has been provided that lack of OPN induces LV dilation which associates with decreased collagen synthesis and deposition. Inhibition of matrix metalloproteinases, key players in ECM remodeling process post-MI, increased ECM deposition (fibrosis) and improved LV function in mice lacking OPN after MI. This review summarizes--1) signaling pathways leading to increased expression of OPN in the heart; 2) the alterations in the structure and function of the heart post-MI in mice lacking OPN; and 3) mechanisms involved in OPN-mediated ECM remodeling post-MI.