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Prognostic value of cerebrospinal fluid neuron-specific enolase and S-100b protein in Guillain-Barré syndrome

2009; Wiley; Volume: 89; Issue: 1 Linguagem: Inglês

10.1111/j.1600-0404.1994.tb01628.x

1600-0404

Kenji Mokuno, Kazuhiro Kiyosawa, K. Sugimura, Takeshi Yasuda, S Riku, Tomoyuki Murayama, Tsutomu Yanagi, Akihisa Takahashi, Keisuke Kato,

Hereditary Neurological Disorders

We measured the cerebrospinal fluid (CSF) concentrations of neuron-specific enolase (NSE) and S-100b protein (S-100b) using enzyme immunoassay methods, in 24 patients with Guillain-Barré syndrome and 46 controls, and examined their prognostic values. Sixteen of 24 patients showed elevated levels (> the mean + 2SD levels of controls) of NSE, S-100b, or both, and in those with higher NSE or S-100b levels there was a rather longer duration of disease, whereas 8 patients with the normal levels showed an early recovery. Further, NSE or S-100b levels were significantly correlated with months to recovery. Thus, NSE and S-100b in CSF may be useful markers for predicting the outcome of Guillain-Barré syndrome.