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Plasma dehydroepiandrosterone sulfate, androstenedione and cortisol, and urinary free cortisol excretion in breast cancer

1977; Pergamon Press; Volume: 13; Issue: 1 Linguagem: Inglês

10.1016/0014-2964(77)90228-6

1879-2995

David P. Rose, P. M. Stauber, Antoinette R. Thiel, Joseph J. Crowley, John R. Milbrath,

Estrogen and related hormone effects

The concentrations of plasma dehydroepiandrosterone sulfate (DS), androstenedione (A2) and cortisol (C), and the urinary free cortisol (UFC) excretion were measured in 24 women with breast cancer before mastectomy and another 45 approximately 1 month after surgery, and in 49 cases of advanced breast cancer. The results were compared with those from a group of healthy women. Plasma DS was negatively correlated with age, and all 3 breast cancer groups showed significantly reduced levels compared with age-comparable controls. Plasma A2 was also negatively correlated with age; no significant difference was found between the cancer patients and controls. The mean levels of plasma C and UFC in the breast cancer patients were normal, but 7 of the 49 (14%) cases of advanced disease did have elevated UFC excretions.