[(η 6 ‐Praziquantel)Cr(CO) 3 ] Derivatives with Remarkable In Vitro Anti‐schistosomal Activity
2013; Wiley; Volume: 19; Issue: 7 Linguagem: Inglês
10.1002/chem.201204291
ISSN1521-3765
AutoresMalay Patra, Katrin Ingram, Vanessa Pierroz, Stefano Ferrari, Bernhard Spingler, Robin B. Gasser, Jennifer Keiser, Gilles Gasser,
Tópico(s)Metal complexes synthesis and properties
ResumoChemistry – A European JournalVolume 19, Issue 7 p. 2232-2235 Communication [(η6-Praziquantel)Cr(CO)3] Derivatives with Remarkable In Vitro Anti-schistosomal Activity Dr. Malay Patra, Dr. Malay Patra Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich (Switzerland), Fax: (+41) 44-635-68-03Search for more papers by this authorKatrin Ingram, Katrin Ingram Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, University of Basel, P.O Box, 4002 Basel (Switzerland), Fax: (+41) 61-284-81-01Search for more papers by this authorVanessa Pierroz, Vanessa Pierroz Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich (Switzerland), Fax: (+41) 44-635-68-03 Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, 8057 Zurich (Switzerland)Search for more papers by this authorPriv.-Doz. Dr. Stefano Ferrari, Priv.-Doz. Dr. Stefano Ferrari Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, 8057 Zurich (Switzerland)Search for more papers by this authorPriv.-Doz. Dr. Bernhard Spingler, Priv.-Doz. Dr. Bernhard Spingler Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich (Switzerland), Fax: (+41) 44-635-68-03Search for more papers by this authorProf. Dr. Robin B. Gasser, Prof. Dr. Robin B. Gasser Faculty of Veterinary Science, The University of Melbourne, Parkville, Victoria 3010 (Australia)Search for more papers by this authorProf. Dr. Jennifer Keiser, Corresponding Author Prof. Dr. Jennifer Keiser [email protected] Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, University of Basel, P.O Box, 4002 Basel (Switzerland), Fax: (+41) 61-284-81-01 Jennifer Keiser, Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, University of Basel, P.O Box, 4002 Basel (Switzerland), Fax: (+41) 61-284-81-01 Gilles Gasser, Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich (Switzerland), Fax: (+41) 44-635-68-03Search for more papers by this authorProf. Dr. Gilles Gasser, Corresponding Author Prof. Dr. Gilles Gasser [email protected] Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich (Switzerland), Fax: (+41) 44-635-68-03 Jennifer Keiser, Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, University of Basel, P.O Box, 4002 Basel (Switzerland), Fax: (+41) 61-284-81-01 Gilles Gasser, Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich (Switzerland), Fax: (+41) 44-635-68-03Search for more papers by this author Dr. Malay Patra, Dr. Malay Patra Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich (Switzerland), Fax: (+41) 44-635-68-03Search for more papers by this authorKatrin Ingram, Katrin Ingram Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, University of Basel, P.O Box, 4002 Basel (Switzerland), Fax: (+41) 61-284-81-01Search for more papers by this authorVanessa Pierroz, Vanessa Pierroz Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich (Switzerland), Fax: (+41) 44-635-68-03 Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, 8057 Zurich (Switzerland)Search for more papers by this authorPriv.-Doz. Dr. Stefano Ferrari, Priv.-Doz. Dr. Stefano Ferrari Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, 8057 Zurich (Switzerland)Search for more papers by this authorPriv.-Doz. Dr. Bernhard Spingler, Priv.-Doz. Dr. Bernhard Spingler Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich (Switzerland), Fax: (+41) 44-635-68-03Search for more papers by this authorProf. Dr. Robin B. Gasser, Prof. Dr. Robin B. Gasser Faculty of Veterinary Science, The University of Melbourne, Parkville, Victoria 3010 (Australia)Search for more papers by this authorProf. Dr. Jennifer Keiser, Corresponding Author Prof. Dr. Jennifer Keiser [email protected] Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, University of Basel, P.O Box, 4002 Basel (Switzerland), Fax: (+41) 61-284-81-01 Jennifer Keiser, Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, University of Basel, P.O Box, 4002 Basel (Switzerland), Fax: (+41) 61-284-81-01 Gilles Gasser, Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich (Switzerland), Fax: (+41) 44-635-68-03Search for more papers by this authorProf. Dr. Gilles Gasser, Corresponding Author Prof. Dr. Gilles Gasser [email protected] Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich (Switzerland), Fax: (+41) 44-635-68-03 Jennifer Keiser, Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, University of Basel, P.O Box, 4002 Basel (Switzerland), Fax: (+41) 61-284-81-01 Gilles Gasser, Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich (Switzerland), Fax: (+41) 44-635-68-03Search for more papers by this author First published: 07 January 2013 https://doi.org/10.1002/chem.201204291Citations: 28Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract The antischistosomal effect of two [(η6-praziquantel)Cr(CO)3] derivatives was investigated. The compounds (see figure: Cr purple, N blue, O red) were prepared in a one-step procedure from commercially available praziquantel. Both derivatives show a high in vitro activity against Schistosoma mansoni, a parasitic trematode, and only a minor cytotoxic effect on selected mammalian cell lines. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Filename Description chem_201204291_sm_miscellaneous_information.pdf427.8 KB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. References 1P. Steinmann, J. Keiser, R. Bos, M. Tanner, J. Utzinger, Lancet Infect. Dis. 2006, 6, 411–425 2C. H. King, Acta Trop. 2010, 113, 95–104. 3 3aR. N. Beech, A. Silvestre, Anti-Infect. Agents Med. Chem. 2010, 9, 105–112; 3bM. J. Doenhoff, D. Cioli, J. Utzinger, Curr. Opin. Infect. Dis. 2008, 21, 659–667. 4 4aM. Ismail, S. Botros, A. Metwally, S. William, A. Farghally, L. F. Tao, T. A. Day, J. L. Bennett, Am. J. Trop. Med. Hyg. 1999, 60, 932–935; 4bS. D. Melman, M. L. Steinauer, C. Cunningham, L. S. Kubatko, I. N. Mwangi, N. B. Wynn, M. W. Mutuku, D. M. S. Karanja, D. G. Colley, C. L. Black, W. E. Secor, G. M. Mkoji, E. S. Loker, PLoS Negl. 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