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Advances in the Care of Children with Spina Bifida

2014; Elsevier BV; Volume: 61; Issue: 1 Linguagem: Inglês

10.1016/j.yapd.2014.03.007

1878-1926

Susan Apkon, Richard Grady, Solveig Hart, Amy Lee, Thomas E. McNalley, Lee Niswander, Juliette R. Petersen, Sheridan Remley, Deborah Rotenstein, Hillary A. Shurtleff, Molly H. Warner, William O. Walker,

Prenatal Screening and Diagnostics

Neural tube defects (NTDs) are a multifactorial disorder that results from a complex combination of genetic and environmental interactions. The worldwide incidence of NTDs ranges from 1.0 to 10.0 per 1000 births in specific geographic locations, with almost equal frequencies between 2 major categories: anencephaly and spina bifida [1,2]. The birth prevalence of NTDs in specific populations is influenced by the availability of prenatal diagnosis and elective pregnancy termination; higher frequencies occur in miscarriage material [3].