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Rapid and Sensitive Loop-Mediated Isothermal Amplification Test for Clostridium difficile Detection Challenges Cytotoxin B Cell Test and Culture as Gold Standard

2010; American Society for Microbiology; Volume: 49; Issue: 2 Linguagem: Inglês

10.1128/jcm.01824-10

1098-660X

Torbjörn Norén, Ingegärd Alriksson, Josefin Andersson, Thomas Åkerlund, Magnus Unemo,

Microscopic Colitis

ABSTRACT Compared to the composite gold standard cytotoxin B assay and toxigenic culture, the loop-mediated isothermal amplification (LAMP) test for Clostridium difficile had a sensitivity and specificity of 98%, positive predictive value of 92%, and negative predictive value of >99%. A one-hour turnaround time for the LAMP test provides rapid diagnosis and cost savings.