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Exercise and cognitive function

2005; Elsevier BV; Volume: 4; Issue: 11 Linguagem: Inglês

10.1016/s1474-4422(05)70203-9

1474-4465

Helen Petrovitch, Lon R. White,

Dementia and Cognitive Impairment Research

In this issue of The Lancet Neurology, Rovio and colleagues 1 Rovio S Kareholt I Eeva-Liisa H et al. Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease. Lancet Neurol. 2005; 4: 705-711 Summary Full Text Full Text PDF PubMed Scopus (797) Google Scholar present results from a large prospective study in eastern Finland. Individuals who reported leisure-time physical activity at least twice a week in midlife had a significantly reduced risk of dementia and Alzheimer's disease a mean of 21 years later compared with those who exercised less often. This relation remained significant after adjustments for age, sex, education, length of follow-up, locomotor disorders, APOE genotype, vascular disorders, smoking, and alcohol use. Rovio and colleagues' findings are supported by shorter prospective studies (follow-up 3–7 years) of cognitively normal elderly people. 2 Abbott RD White LR Ross GW Masaki KH Curb JD Petrovitch H Walking and dementia in physically capable elderly men. JAMA. 2004; 292: 1447-1453 Crossref PubMed Scopus (591) Google Scholar , 3 Podewils LJ Guallar E Kuller LH et al. Physical activity, APOE genotype, and dementia risk: findings from the Cardiovascular Health Cognition Study. Am J Epidemiol. 2005; 161: 639-651 Crossref PubMed Scopus (521) Google Scholar In the Honolulu-Asia Aging Study, after adjustment for age, retired Japanese-American men who did not walk much (less than 0·25 miles [0·40 km] per day) had a 1·8 times increased risk of dementia compared with those who walked more than 2 miles (3·21 km) per day. 2 Abbott RD White LR Ross GW Masaki KH Curb JD Petrovitch H Walking and dementia in physically capable elderly men. JAMA. 2004; 292: 1447-1453 Crossref PubMed Scopus (591) Google Scholar Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's diseaseLeisure-time physical activity at midlife is associated with a decreased risk of dementia and AD later in life. Regular physical activity may reduce the risk or delay the onset of dementia and AD, especially among genetically susceptible individuals. Full-Text PDF