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Factors affecting the spontaneous expulsion of the levonorgestrel-releasing intrauterine system

2014; Elsevier BV; Volume: 126; Issue: 2 Linguagem: Inglês

10.1016/j.ijgo.2014.02.017

1879-3479

Jina Youm, Hyun Ju Lee, Seul Ki Kim, Hoon Kim, Byung Chul Jee,

Uterine Myomas and Treatments

International Journal of Gynecology & ObstetricsVolume 126, Issue 2 p. 165-169 Clinical articles Factors affecting the spontaneous expulsion of the levonorgestrel-releasing intrauterine system Jina Youm, Jina Youm Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, Republic of KoreaAuthors contributed equally.Search for more papers by this authorHyun Ju Lee, Hyun Ju Lee Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, Republic of KoreaAuthors contributed equally.Search for more papers by this authorSeul Ki Kim, Seul Ki Kim Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Republic of KoreaSearch for more papers by this authorHoon Kim, Hoon Kim Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, Republic of KoreaSearch for more papers by this authorByung Chul Jee, Corresponding Author Byung Chul Jee [email protected] Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of KoreaCorresponding author at: Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 166 Gumi-ro, Bundang-gu, Seongnam 463–707, Republic of Korea. Tel.: + 82 31 787 7254; fax: + 82 31 787 4054.Search for more papers by this author Jina Youm, Jina Youm Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, Republic of KoreaAuthors contributed equally.Search for more papers by this authorHyun Ju Lee, Hyun Ju Lee Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, Republic of KoreaAuthors contributed equally.Search for more papers by this authorSeul Ki Kim, Seul Ki Kim Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Republic of KoreaSearch for more papers by this authorHoon Kim, Hoon Kim Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, Republic of KoreaSearch for more papers by this authorByung Chul Jee, Corresponding Author Byung Chul Jee [email protected] Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of KoreaCorresponding author at: Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 166 Gumi-ro, Bundang-gu, Seongnam 463–707, Republic of Korea. Tel.: + 82 31 787 7254; fax: + 82 31 787 4054.Search for more papers by this author First published: 18 April 2014 https://doi.org/10.1016/j.ijgo.2014.02.017Citations: 27 Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Objective To estimate the incidence of, and identify risk factors for, spontaneous expulsion of the levonorgestrel-releasing intrauterine system (LNG-IUS). Methods Pre-insertion characteristics for 481 women who received the LNG-IUS at a single institution in the Republic of Korea between 2003 and 2011 were analyzed retrospectively. The median duration of follow-up was 13.4 months. Kaplan–Meier plots were constructed to estimate the time to occurrence of spontaneous expulsion in multiple subgroups. Results The overall crude incidence of spontaneous LNG-IUS expulsion was 9.6%. The cumulative incidence was 7.9%, 9.1%, and 9.6% at 1, 2, and 3 years, respectively. It was significantly higher in women with adenomyosis (9.1%, 10.6%, and 11.1%) or uterine leiomyoma (14.5%, 15.8%, and 15.8%) than in those with a normal uterus (3.6%, 4.1%, and 4.6%) (P = 0.008). Women with heavy menstrual bleeding (11.0%, 12.7%, and 13.4%), dysmenorrhea (8.1%, 9.0%, and 10.0%), or pre-insertion receipt of gonadotropin-releasing hormone agonists (13.3%, 16.0%, and 17.3%) also had higher cumulative incidences than those without these conditions (P < 0.05). 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