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The Complementary Competitors: Palladium and Copper in C–N Cross-Coupling Reactions

2012; American Chemical Society; Volume: 31; Issue: 22 Linguagem: Inglês

10.1021/om300683c

1520-6041

I. P. Beletskaya, Andrei V. Cheprakov,

Asymmetric Hydrogenation and Catalysis

The C–N cross-coupling chemistry intensely developed since the late 1990s has supplied synthesists with an overwhelming number of methods to effectively combine carbon and nitrogen residues. This new chemistry relies on complexes of mainly two metals, copper and palladium, used as catalysts or stoichiometric agents. The development of new methods has revealed both similarities and differences in the principles used for the design of new catalytic systems and analysis of their reactivity and selectivity. The discussion of cross-coupling chemistry of these two metals can be performed within a common mechanistic paradigm, helping to elucidate the key factors governing the behavior of the transition-metal complexes involved.