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Induction of Cytokine Production from Human Monocytes Stimulated with Alginate

1991; Lippincott Williams & Wilkins; Volume: 10; Issue: 4 Linguagem: Inglês

10.1097/00002371-199108000-00007

1537-4513

Marit Otterlei, Kjetill Østgaard, Gudmund Skjåk‐Bræk, Olav Smidsrød, Patrick Soon‐Shiong, Terje Espevik,

Seaweed-derived Bioactive Compounds

Summary: Alginates are polysaccharides with gel-forming properties composed of 1,4-linked β-D-mannuronic acid (M), α-L-guluronic acid (G), and alternating (MG) blocks. Alginate can be used as a matrix for implanted cells in vivo. In this study, we have examined the ability of alginates and their components to stimulate human monocytes to produce tumor necrosis factor-a, interleukin-6, and interleukin-1. Alginates stimulated the monocytes to produce high levels of all three cytokines. Low G alginates were approximately 10 times more potent in inducing cytokine production compared with high G alginates. The M-blocks and the MG-blocks, but not the G-blocks, stimulated the cytokine production. The results demonstrate that the mannuronic acid residues are the active cytokine inducers in alginates.