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BIBTEX RIS

Minimally modified electronegative LDL and its autoantibodies in acute and chronic coronary syndromes

2006; Elsevier BV; Volume: 39; Issue: 7 Linguagem: Inglês

10.1016/j.clinbiochem.2006.05.002

1873-2933

Jair Aparecido de Oliveira, Alex Sevanian, Ricardo José Rodrigues, Elaine Apolinário, Dulcinéia Saes Parra Abdalla,

Antioxidant Activity and Oxidative Stress

To determine the minimally modified electronegative LDL (LDL-) and its autoantibodies in coronary syndromes.LDL(-) and its autoantibodies were determined by ELISA in patients with acute (ACS, unstable angina; AMI, acute myocardial infarction) and chronic coronary syndromes (stable angina, SA) and compared to subjects without coronary disease (controls). Results are expressed as median of LDL- (microg/mL) and anti-LDL(-) IgG (OD405 nm).The concentrations of LDL(-) were higher in patients with coronary disease (ACS: 40.7 microg/mL; SA: 35.0 microg/mL) as compared to controls (21.6 microg/mL). The highest LDL- concentrations were found in patients with AMI (41.8 microg/mL). Anti-LDL(-) IgG was elevated in ACS (1.143) in relation to CCS (0.527) and controls (0.467). A positive correlation was observed between anti-LDL- IgG and CRP levels (r = 0.34, p <0.01) in the studied groups.LDL(-) and anti-LDL(-) autoantibodies may be useful markers to follow patients with high risk for coronary events.