Produção Nacional
Prevalência da macroprolactinemia entre 115 pacientes com hiperprolactinemia
2007; Editora da Universidade de São Paulo; Volume: 51; Issue: 1 Linguagem: Inglês
10.1590/s0004-27302007000100014
ISSN1677-9487
AutoresLúcio Vilar, Eliane Moura, Viviane Canadas, Amaro Gusmão, Renata Campos, Edmundo Leal, Luciano Teixeira, Vera Santos, Bárbara Gomes, Marise Lima, Renata Paiva, José Luciano Albuquerque, Célia S. Egito, Carlos Augusto de Oliveira Botelho, Monalisa Ferreira Azevedo, Luíz Augusto Casulari, Luciana Ansaneli Naves,
Tópico(s)Ovarian function and disorders
ResumoMacroprolactinemia is characterized by the predominance in the serum of macroprolactin, a prolactin (PRL) with high molecular mass and low biological activity that does not need treatment. The prevalence of macroprolactinemia was evaluated in 115 consecutive patients with hyperprolactinemia. Among them, 19 (16.5%) had solely macroprolactinemia, 4 (3.5%) polycystic ovary syndrome, 7 (6.1%) acromegaly, 8 (6.9%) idiopathic hyperprolactinemia, 10 (8.6%) primary hypothyroidism, 14 (12.2%) clinically non-functioning pituitary adenomas, 20 (17.4%) drug-induced hyperprolactinemia and 33 (28.7%) prolactinomas. The diagnosis of macroprolactinemia was established by the demonstration of a PRL recovery < 30% after treatment of sera with polyethylene glycol. Among the 19 patients with isolated macroprolactinemia, 16 (84.2%) were female and 12 (63.2%) were asymptomatic, while 4 (21%) presented with oligomenorrhea and 3 (15.8%) with galactorrhea. In contrast, only 11.5% of individuals with other causes of hyperprolactinemia were asymptomatic (p< 0.001). Prolactin levels in cases of macroprolactin ranged from 45.1 to 404 ng/mL (mean 113.3 +/- 94.5) but in 15 (78.9%) were < 100 ng/mL. Our findings demonstrate that macroprolactinemia is a common condition and, therefore, we suggest that it should be routinely screened in patients with hyperprolactinemia.
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