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Physiological and pathological relevance of secretory microRNAs and a perspective on their clinical application

2013; De Gruyter; Volume: 395; Issue: 4 Linguagem: Inglês

10.1515/hsz-2013-0222

1437-4315

Takeshi Katsuda, Shingo Ikeda, Yusuke Yoshioka, Nobuyoshi Kosaka, Masaki Kawamata, Takahiro Ochiya,

RNA Interference and Gene Delivery

Abstract MicroRNAs (miRNAs) have attracted significant attention because of their important roles in a variety of physiological and pathological processes. Recent studies have shown that many cell types secrete miRNAs by packaging them into lipid-bilayered small vesicles called exosomes. Furthermore, exosomal miRNAs travel between cells, exert their RNAi effects in the recipient cells, and play important roles in various biological processes. In this article, we will summarize and describe the latest studies on exosomal miRNAs by focusing on their roles in cancer progression, immune regulation, and tissue repair. We will also provide a perspective on the clinical applications of this research field.