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BIBTEX RIS

Atomic Force Microscopy Applied to the Characterization of Solid Lipid Nanoparticles

2005; Oxford University Press; Volume: 11; Issue: S03 Linguagem: Inglês

10.1017/s1431927605050877

1435-8115

Felipe Peixoto, P. Menezes Dias, Gilson Andrade Ramaldes, José Mário Carneiro Vilela, Margareth Spangler Andrade, Armando Silva‐Cunha,

Advancements in Transdermal Drug Delivery

Solid lipid nanoparticles (SLN) have generated increasing attention as an alternative carrier system, particularly for lipophilic drugs [1-2]. The system consists of lipid nanoparticles, which are solid at room temperature. The solid matrix offers the possibility to improve the stability against coalescence and the reduced mobility of incorporated drug molecules is a pre requisite for controlled drug release [3]. Dexamethasone acetate was used as a model drug because of its wide application in the pharmaceutical field and lipophilic properties.