Effect of α1-adrenoceptors blockade with prazosin in canine narcolepsy
1988; Elsevier BV; Volume: 444; Issue: 1 Linguagem: Inglês
10.1016/0006-8993(88)90927-4
ISSN1872-6240
AutoresEmmanuel Mignot, Christian Guilleminault, S. Scott Bowersox, Alain Rappaport, William C. Dement,
Tópico(s)Biochemical Analysis and Sensing Techniques
ResumoThe role of central α1-adrenergic receptors in cataplexy was investigated in 4 narcoleptic poodles and 6 genetically narcoleptic Doberman pinschers. Treatment of narcoleptic dogs with prazosin, a selective α1-adrenergic receptor blocker, exacerbated cataplexy in both narcoleptic dog breeds. Control and heterozygous Dobermans were not affected by the drug. Binding studies using [3H]prazosin revealed an increase in α1-receptor binding apparently limited to the amygdala. The present study suggests that central α1-adrenoceptors, whose role is still mostly unknown, play a fundamental role in controlling mechanisms involved in cataplexy and REM sleep.
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