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A Case of Recurrent Malignant Pheochromocytoma Complicated by Watery Diarrhea, Hypokalemia, Achlorhydria Syndrome

1987; Oxford University Press; Volume: 65; Issue: 5 Linguagem: Inglês

10.1210/jcem-65-5-1053

1945-7197

Kazuo Nigawara, Tadashi Suzuki, Hiroshi Tazawa, Tomihisa Funyu, Soroku Yagihashi, Kanemitsu Yamaya, Yuriko Terayama, Ken Yamaguchi,

Neuroendocrine Tumor Research Advances

A patient is reported who had undergone right adrenalectomy for pheochromocytoma and 15 yr later developed a recurrence in the same site complicated by the watery diarrhea, hypokalemia, achlorhydria syndrome. This tumor was histologically defined as a composite malignant pheochromocytomaganglioneuroblastoma (well differentiated type). Vasoactive intestinal polypeptide and catecholamine concentrations were elevated in both plasma and the tumor. The tumor somatostatin content also was high. The tumor was immunohistochemically determined to contain both vasoactive intestinal polypeptide and somatostatin.