Assignment of genes to regions of mouse chromosomes.
1978; National Academy of Sciences; Volume: 75; Issue: 2 Linguagem: Inglês
10.1073/pnas.75.2.946
ISSN1091-6490
AutoresEva M. Eicher, Linda L. Washburn,
Tópico(s)Genomics and Chromatin Dynamics
ResumoA genetic mapping procedure, called the duplication-deficiency method, is described. This method permits the genetic location of a translocation to be determined within a linkage group without the use of recombination. By utilizing the duplication-deficiency method to define the genetic breakpoints for a series of translocations involving a given chromosome and integrating this information with their cytological breakpoints, obtained by Giemsa banding, a genetic map of the chromosomes is constructed whereby groups of loci are assigned to banded regions. Duplication-deficiency mapping and Giemsa banding analysis of the T(X;7)1Ct and T(7;19)145H translocations together with information from the c25H deletion have permitted mouse chromosome 7 to be divided into six and chromosome 19 into two definable genetic regions.
Referência(s)