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Selective engraftment of donor CD4+25high FOXP3-positive T cells in IPEX syndrome after nonmyeloablative hematopoietic stem cell transplantation

2009; Elsevier BV; Volume: 113; Issue: 22 Linguagem: Inglês

10.1182/blood-2009-02-206359

1528-0020

Markus G. Seidel, G. Fritsch, Thomas Lion, Birgit Jürgens, Andreas Heitger, Rosa Bacchetta, Ánita Lawitschka, Christina Peters, Helmut Gadner, Susanne Matthes‐Martin,

T-cell and B-cell Immunology

To the editor: Mutations of FoxP3 result in the disturbance of FoxP3 expression and lack of functional CD4+CD25high regulatory T cells in humans, causing immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. The only curative approach for IPEX syndrome, which is fatal