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The relationship between T-lymphocyte subset infiltration and survival in patients with prostate cancer

2004; Springer Nature; Volume: 91; Issue: 3 Linguagem: Inglês

10.1038/sj.bjc.6601943

1532-1827

Peter McArdle, Khalid Canna, Donald C. McMillan, A. M. McNicol, R Campbell, M.A. Underwood,

Prostate Cancer Treatment and Research

The relationship between tumour stage, T-lymphocyte subset infiltration and survival was examined in patients with prostate cancer (n=80). On multivariate analysis PSA (HR 2.47, 95% CI 1.27-4.83, P=0.008) and CD4+ T-lymphocyte count (HR 2.29, 95% CI 1.25-4.22, P=0.008) had independent significance. Increased CD4+ T-lymphocyte infiltration within the tumour was stage independent and associated with poor outcome in patients with prostate cancer.