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Cytotoxic Polyprenylated Xanthones from the Resin of Garcinia hanburyi

2006; Pharmaceutical Society of Japan; Volume: 54; Issue: 2 Linguagem: Inglês

10.1248/cpb.54.265

1347-5223

Quan‐Bin Han, Yulin Wang, Ling Yang, Ting‐Fai Tso, Chun‐Feng Qiao, Jing‐Zheng Song, Lijia Xu, Shilin Chen, Dajian Yang, Hong‐Xi Xu,

Biological Activity of Diterpenoids and Biflavonoids

Thirteen xanthones (1-13) were isolated from the resin of Garcinia hanburyi. Among them, two new compounds (namely gaudichaudic acid, and isogambogenic acid, 1, 2), and one new natural product (deoxygaudichaudione A, 3) were identified on the basis of extensive spectral evidence including detailed 2D NMR data. Ten of these xanthones were tested for their cytotoxicities against human leukemia K562 (K562/S) and doxorubicin-resistant K562 (K562/R) cell lines, and showed similar inhibitory effects on both cell lines, suggesting that this group of polyprenylated xanthones might not be multidrug resistance (MDR) substrates.