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Enzymatic synthesis of optically active 2-methyl- and 2,2-dimethylcyclopropanecarboxylic acids and their derivatives

2002; Elsevier BV; Volume: 18; Issue: 4-6 Linguagem: Inglês

10.1016/s1381-1177(02)00105-4

1873-3158

Mei‐Xiang Wang, Guoqiang Feng,

Carbohydrate Chemistry and Synthesis

Catalyzed by Rhodococcus sp. AJ270 microbial cells under very mild conditions, racemic 2,2-dimethylcyclopropanecarbonitrile (1) and its amide (2), and trans- and cis-2-methylcyclopropanecarboxamides (4) and (7) underwent enantioselective hydrolysis to give the corresponding optically active amides and acids.