Portal de Periódicos da CAPES

Synthesis and Evaluation of a Bimodal CXCR4 Antagonistic Peptide

2011; American Chemical Society; Volume: 22; Issue: 5 Linguagem: Inglês

10.1021/bc2000947

1520-4812

Joeri Kuil, Tessa Buckle, Hushan Yuan, Nynke S. van den Berg, Shinya Oishi, Nobutaka Fujii, Lee Josephson, Fijs W. B. van Leeuwen,

Monoclonal and Polyclonal Antibodies Research

The antagonistic Ac-TZ14011 peptide, which binds to the chemokine receptor 4, has been labeled with a multifunctional single attachment point reagent that contains a DTPA chelate and a fluorescent dye with Cy5.5 spectral properties. Flow cytometry and confocal microscopy showed that the bimodal labeled peptide gave a specific receptor binding that is similar to monofunctionalized peptide derivatives. Therefore, the newly developed bimodal peptide derivative can be used in multimodal imaging applications.