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Comparison Between Mucinous Cystic Neoplasm and Intraductal Papillary Mucinous Neoplasm of the Branch Duct Type of the Pancreas With Respect to Expression of CD10 and Cytokeratin 20

2009; Lippincott Williams & Wilkins; Volume: 38; Issue: 5 Linguagem: Inglês

10.1097/mpa.0b013e31819f3bd6

1536-4828

Takashi Nishigami, Masayuki Onodera, Ikuko Torii, Ayuko Sato, Lihua Tao, Ryoji Kushima, Ayako Kakuno, Mitsuo Kishimoto, Eiji Katsuyama, Takahiro Fujimori, Hiroshi Hirano, Makoto Satake, Nobukazu Kuroda, Shuhei Nishiguchi, Jiro Fujimoto, Tohru Tsujimura,

Neuroendocrine Tumor Research Advances

Objective: Mucinous cystic neoplasm (MCN) and intraductal papillary mucinous neoplasm of the branch duct type (IPMN-BD) differ in biological and clinical behaviors, but MCN is often misdiagnosed as IPMN-BD. The purpose of this study was to find useful markers for the differential diagnosis of MCN and IPMN-BD. Methods: Immunohistochemically, the expression of the 2 types of mucin (MUC) 1 (MUC1/DF3 and MUC1/CORE), MUC2, MUC5AC, MUC6, human gastric mucin (HGM), caudal-related homeobox transcription factor 2 (CDX2), CD10, cytokeratin (CK) 7, and CK20 was examined in 7 cases of MCN and 16 cases of IPMN-BD. Results: Expression frequencies in MCN and IPMN-BD were 100% versus 44% for MUC1/DF3, 86% versus 31% for MUC1/CORE, 57% versus 19% for MUC2, 86% versus 100% for MUC5AC, 57% versus 88% for MUC6, 86% versus 100% for HGM, 57% versus 0% for CDX2, 71% versus 0% for CD10, 100% versus 69% for CK7, and 86% versus 6% for CK20. Conclusions: Mucin 1/DF3, MUC1/CORE, CDX2, CD10, and CK20 were expressed significantly more frequently in MCN than in IPMN-BD. In particular, CD10 and CK20 showed marked differences in immunohistochemical sensitivity and specificity between MCN and IPMN-BD. It is therefore proposed that CD10 and CK20 may be used for the differential diagnosis of MCN and IPMN-BD.