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HEMODYNAMIC EFFECTS OF TRANSURETHRAL ALPROSTADIL MEASURED BY COLOR DUPLEX ULTRASONOGRAPHY IN MEN WITH ERECTILE DYSFUNCTION

1998; Lippincott Williams & Wilkins; Volume: 160; Issue: 4 Linguagem: Inglês

10.1016/s0022-5347(01)62526-6

1527-3792

PETER Y. TAM, T Keller, R. Poppiti, Neil Gesundheit, Harin Padma-Nathan,

Hormonal and reproductive studies

No AccessJournal of UrologyClinical Urology: Original Articles1 Oct 1998HEMODYNAMIC EFFECTS OF TRANSURETHRAL ALPROSTADIL MEASURED BY COLOR DUPLEX ULTRASONOGRAPHY IN MEN WITH ERECTILE DYSFUNCTION PETER Y. TAM, TINA KELLER, ROBERTA POPPITI, NEIL GESUNDHEIT, and HARIN PADMA-NATHAN PETER Y. TAMPETER Y. TAM Shareholder and/or employee of VIVUS, Inc. More articles by this author , TINA KELLERTINA KELLER More articles by this author , ROBERTA POPPITIROBERTA POPPITI More articles by this author , NEIL GESUNDHEITNEIL GESUNDHEIT Shareholder and/or employee of VIVUS, Inc. More articles by this author , and HARIN PADMA-NATHANHARIN PADMA-NATHAN Supported by a grant from VIVUS, Inc. More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)62526-6AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We evaluated the hemodynamic effects of transurethral alprostadil in 21 patients with erectile dysfunction using color duplex ultrasonography. Materials and Methods: Penile arterial diameter, peak flow velocity and end diastolic velocity were compared following intraurethral administration of 500 micro g. alprostadil and intracavernosal injection of 10 micro g. alprostadil. Results: A dose of 500 micro g. transurethral alprostadil resulted in significant increases in corporeal blood flow comparable to those achieved with intracavernosal injection of 10 micro g. alprostadil as measured by duplex ultrasonography in men with erectile dysfunction. Transurethral alprostadil resulted in statistically significant increases in arterial diameter and peak flow velocity comparable to those achieved with intracavernosal injection. End diastolic velocities were higher after transurethral alprostadil than intracavernosal injections. Color ultrasonography following transurethral alprostadil showed arterial and venous hyperemia of the corpus spongiosum and corpora cavernosa. Furthermore, color ultrasonography revealed communicating vessels between the corpus spongiosum and corpora cavernosa following administration of transurethral alprostadil. Conclusions: The visualization of communicating vessels between the corpus spongiosum and corpora cavernosa after transurethral alprostadil suggests local mechanisms of drug transfer from one to the other. In addition to potential clinical benefits, transurethral alprostadil may be useful to visualize the vascular anatomy of the penis and to test for patient responsiveness to local vasoactive agents. References 1 : Medical progress-impotence. New Engl. J. Med.1989; 321: 1648. Google Scholar 2 : Evaluation of vasculogenic impotence using penile duplex ultrasonography. J. Urol.1989; 142: 1469. Abstract, Google Scholar 3 : Penile duplex sonography in the diagnosis of venogenic impotence. J. Vasc. Surg.1991; 13: 75. Google Scholar 4 : Penile vascular assessment using color duplex sonography in men with Peyronie's disease. J. Urol.1996; 155: 1270. Link, Google Scholar 5 : Functional evaluation of penile arteries with duplex ultrasound in vasodilator-induced erection. Urol. Clin. N. Amer.1989; 16: 799. Google Scholar 6 : NIH Consensus Development Panel on Impotence. J.A.M.A.1993; 270: 83. 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Efficiency and incidence of priapism. Brit. J. Urol.1990; 65: 68. Google Scholar 14 : Treatment of men with erectile dysfunction with transurethral alprostadil. Medicated Urethral System for Erection (MUSE) Study Group. New Engl. J. Med.1997; 336: 1. Google Scholar 15 : A double-blind, placebo-controlled evaluation of the erectile response to transurethral alprostadil. Urology1996; 48: 851. Google Scholar 16 : Timing of penile color flow duplex ultrasonography using a triple drug mixture. J. Urol.1995; 153: 1472. Link, Google Scholar 17 : Functional anatomy and mechanism of penile erection. In: Contemporary Management of Impotence and Infertility. Edited by . Baltimore: Williams & Wilkins1988: 39. chapt 4. Google Scholar From the Department of Clinical Research, VIVUS, Inc., Mountain View and Department of Urology, University of Southern California, Los Angeles, CaliforniaPresented at annual meeting of American Urological Association, San Francisco, California, May 14-19, 1994.© 1998 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 160Issue 4October 1998Page: 1321-1324 Advertisement Copyright & Permissions© 1998 by American Urological Association, Inc.MetricsAuthor Information PETER Y. TAM Shareholder and/or employee of VIVUS, Inc. More articles by this author TINA KELLER More articles by this author ROBERTA POPPITI More articles by this author NEIL GESUNDHEIT Shareholder and/or employee of VIVUS, Inc. More articles by this author HARIN PADMA-NATHAN Supported by a grant from VIVUS, Inc. More articles by this author Expand All Advertisement PDF downloadLoading ...