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Dysproteinemic Purpura of the Hypergammaglobulinemic Type

1958; American Medical Association; Volume: 77; Issue: 1 Linguagem: Inglês

10.1001/archderm.1958.01560010025005

2375-6772

George W. Hambrick,

Blood disorders and treatments

Dysproteinemic purpura is a more or less chronic condition characterized by purpura and by a serum protein pattern which is abnormal qualitatively, quantitatively, or both. Three types of this condition have been recognized. In 1943 "purpura hyperglobulinemica" was described by Waldenström 1 ; in his patients purpura of the legs of a chronic, recurrent type was accompanied by an increase in serum γ-globulin and elevated sedimentation rate without definite, recognizable systemic disease. Subsequently, macroglobulinemia of Waldenström 2,3 in 1944 and cryoglobulinemia of Lerner and Watson 4 in 1947 were recognized as distinct dysproteinemic syndromes with hyperglobulinemia. Lerner and Watson stated that purpura cryoglobulinemica could be considered a special type of purpura hyperglobulinemica of Waldenström. In this paper "dysproteinemic purpura of the hypergammaglobulinemic type" will be used to designate the original syndrome of "purpura hyperglobulinemica of Waldenström." * Although a peculiar, hyperpigmented purpura of the legs is the