Copper-Catalyzed Carbene Insertion into O−H Bonds: High Selective Conversion of Alcohols into Ethers
2003; American Chemical Society; Volume: 22; Issue: 14 Linguagem: Inglês
10.1021/om030243a
ISSN1520-6041
AutoresM. Esther Morilla, Mauricio Molina, M. Mar Díaz‐Requejo, Tomás R. Belderraín, M. Carmen Nicasio, Swiatoslaw Trofimenko, Pedro J. Pérez,
Tópico(s)Asymmetric Hydrogenation and Catalysis
ResumoThe complexes TpXCu (TpX = homoscorpionate ligands) efficiently catalyze the insertion of the carbene fragment :CHCO2Et, generated from ethyl diazoacetate, into the OH bond of saturated and unsaturated alcohols, under mild conditions. In the case of unsaturated alcohols, the reaction proceeds selectively toward the insertion product, and in no case has the addition product been observed.
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