Produção Nacional
Revisado por pares
Serum Retinol Concentrations in Hospitalized Severe Protein-energy Malnourished Children
2008; Oxford University Press; Volume: 54; Issue: 4 Linguagem: Inglês
10.1093/tropej/fmn018
ISSN1465-3664
AutoresMaria de Fátima Costa Caminha, Alcides da Silva Diniz, Ana Rodrigues Falbo, Ilma Kruze Grande de Arruda, Vilneide Maria Santos Braga Diégues Serva, Luciano Lira de Albuquerque, Margarida Maria de Freitas Lóla, G. J. Ebrahim,
Tópico(s)Child Nutrition and Water Access
ResumoBackground: Vitamin A deficiency (VAD) is a major nutritional problem in many developing countries. Vitamin A status has been reported to be adversely affected in protein-energy malnutrition (PEM). Objective: to assess and compare serum retinol concentrations in hospitalized children with severe PEM and normal ones. Methods: a prospective series of 34 malnourished and 29 normal control children, <60 months old, hospitalized at IMIP, Recife-PE were recruited for the study between August 2004 and May 2005. Serum retinol level was assayed by high performance liquid chromatography and concentrations adjusted for presence of inflammation as evidenced by levels of C-reactive protein. Blood retinol level was compared according to nutritional status (severe PEM versus normal), gender, age, maternal schooling, family income, breastfeeding practice, residence and perceived morbidity. Results: the prevalence of low serum retinol ( 0.05), age (p > 0.05), maternal schooling (p > 0.05), family income (p > 0.05), breastfeeding practice (p > 0.05) and residence (p > 0.05). However, malnourished children with diarrhoea showed lower serum retinol concentrations (p = 0.021) compared to those without diarrhoea. Conclusion: VAD was prevalent in hospitalized children with severe PEM and also among normal ones although in lesser magnitude. Intervention for prevention and control of deficiency of vitamin A are recommended in settings where diarrhea is endemic and there are unfavorable socio-economical conditions.
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