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Carcinogens are mutagens: their detection and classification.

1973; National Institute of Environmental Health Sciences; Volume: 6; Linguagem: Inglês

10.1289/ehp.7306115

1552-9924

B N Ames,

Carcinogens and Genotoxicity Assessment

Research ArticleOpen AccessCarcinogens are mutagens: their detection and classification. B N Ames B N Ames Published:1 December 1973https://doi.org/10.1289/ehp.7306115Cited by:31AboutSectionsPDF ToolsDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InReddit FiguresReferencesRelatedDetailsCited by Dobrovolsky V and Heflich R (2018) Detecting Mutations In Vivo Mutagenicity: Assays and Applications, 10.1016/B978-0-12-809252-1.00011-0, (229-249), . Creager A (2018) Human bodies as chemical sensors: A history of biomonitoring for environmental health and regulation, Studies in History and Philosophy of Science Part A, 10.1016/j.shpsa.2018.05.010, Online publication date: 1-May-2018. Frank S (2015) Commentary: The nature of cancer research, International Journal of Epidemiology, 10.1093/ije/dyv200, 45:3, (638-645), Online publication date: 1-Jun-2016. Nersesyan A, Fenech M, Bolognesi C, Mišík M, Setayesh T, Wultsch G, Bonassi S, Thomas P and Knasmüller S (2016) Use of the lymphocyte cytokinesis-block micronucleus assay in occupational biomonitoring of genome damage caused by in vivo exposure to chemical genotoxins: Past, present and future, Mutation Research/Reviews in Mutation Research, 10.1016/j.mrrev.2016.05.003, 770, (1-11), Online publication date: 1-Oct-2016. MacGregor J, Frötschl R, White P, Crump K, Eastmond D, Fukushima S, Guérard M, Hayashi M, Soeteman-Hernández L, Kasamatsu T, Levy D, Morita T, Müller L, Schoeny R, Schuler M, Thybaud V and Johnson G (2015) IWGT report on quantitative approaches to genotoxicity risk assessment I. Methods and metrics for defining exposure–response relationships and points of departure (PoDs), Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 10.1016/j.mrgentox.2014.09.011, 783, (55-65), Online publication date: 1-May-2015. Claxton L (2015) The history, genotoxicity, and carcinogenicity of carbon-based fuels and their emissions. Part 3: Diesel and gasoline, Mutation Research/Reviews in Mutation Research, 10.1016/j.mrrev.2014.09.002, 763, (30-85), Online publication date: 1-Jan-2015. MacGregor J, Frötschl R, White P, Crump K, Eastmond D, Fukushima S, Guérard M, Hayashi M, Soeteman-Hernández L, Johnson G, Kasamatsu T, Levy D, Morita T, Müller L, Schoeny R, Schuler M and Thybaud V (2015) IWGT report on quantitative approaches to genotoxicity risk assessment II. Use of point-of-departure (PoD) metrics in defining acceptable exposure limits and assessing human risk, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 10.1016/j.mrgentox.2014.10.008, 783, (66-78), Online publication date: 1-May-2015. Araya S, Lovsin-Barle E and Glowienke S (2015) Mutagenicity assessment strategy for pharmaceutical intermediates to aid limit setting for occupational exposure, Regulatory Toxicology and Pharmacology, 10.1016/j.yrtph.2015.10.001, 73:2, (515-520), Online publication date: 1-Nov-2015. Claxton L (2014) The history, genotoxicity, and carcinogenicity of carbon-based fuels and their emissions: 1. Principles and background, Mutation Research/Reviews in Mutation Research, 10.1016/j.mrrev.2014.07.001, 762, (76-107), Online publication date: 1-Oct-2014. Ruan E, Juárez M, Thacker R, Yang X, Dugan M and Aalhus J (2014) Dietary vitamin E effects on the formation of heterocyclic amines in grilled lean beef, Meat Science, 10.1016/j.meatsci.2013.09.016, 96:2, (849-853), Online publication date: 1-Feb-2014. Lapchak P (2012) Drug-Like Property Profiling of Novel Neuroprotective Compounds to Treat Acute Ischemic Stroke: Guidelines to Develop Pleiotropic Molecules, Translational Stroke Research, 10.1007/s12975-012-0200-y, 4:3, (328-342), Online publication date: 1-Jun-2013. Aubrecht J and Caba E (2011) Genomics in Identifying Mutagenic Mode of Action in Carcinogenesis Applications of Toxicogenomics in Safety Evaluation and Risk Assessment, 10.1002/9781118001042.ch5, (81-98) Felter S, Conolly R, Bercu J, Bolger P, Boobis A, Bos P, Carthew P, Doerrer N, Goodman J, Harrouk W, Kirkland D, Lau S, Llewellyn G, Preston R, Schoeny R, Schnatter A, Tritscher A, van Velsen F and Williams G (2011) A proposed framework for assessing risk from less-than-lifetime exposures to carcinogens, Critical Reviews in Toxicology, 10.3109/10408444.2011.552063, 41:6, (507-544), Online publication date: 1-Jul-2011. Paules R, Aubrecht J, Corvi R, Garthoff B and Kleinjans J (2010) Moving Forward in Human Cancer Risk Assessment, Environmental Health Perspectives, 119:6, (739-743), Online publication date: 1-Jun-2011. Kirsanov K, Lesovaya E, Yakubovskaya M and Belitsky G (2010) SYBR Gold and SYBR Green II are not mutagenic in the Ames test, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 10.1016/j.mrgentox.2010.04.014, 699:1-2, (1-4), Online publication date: 1-Jun-2010. McGregor D, Boobis A, Binaglia M, Botham P, Hoffstadt L, Hubbard S, Petry T, Riley A, Schwartz D and Hennes C (2009) Guidance for the classification of carcinogens under the Globally Harmonised System of Classification and Labelling of Chemicals (GHS), Critical Reviews in Toxicology, 10.3109/10408440903384717, 40:3, (245-285), Online publication date: 1-Mar-2010. Boobis A, Cohen S, Doerrer N, Galloway S, Haley P, Hard G, Hess F, Macdonald J, Thibault S, Wolf D and Wright J (2009) A Data-Based Assessment of Alternative Strategies for Identification of Potential Human Cancer Hazards, Toxicologic Pathology, 10.1177/0192623309343779, 37:6, (714-732), Online publication date: 1-Oct-2009. Caba E and Aubrecht J (2008) Functional Genomic Approaches for Studying Genotoxicity and Carcinogenesis Genomics, 10.3109/9781420067064-10, (207-221), Online publication date: 9-Oct-2008. Amor-Guéret M (2006) Bloom syndrome, genomic instability and cancer: the SOS-like hypothesis, Cancer Letters, 10.1016/j.canlet.2005.04.023, 236:1, (1-12), Online publication date: 1-May-2006. Caba E and Aubrecht J (2008) Genomic Approaches for Investigating Mechanisms of Genotoxicity, Toxicology Mechanisms and Methods, 10.1080/15376520600558291, 16:2-3, (69-77), Online publication date: 1-Jan-2006. Dog T, Powell K and Weisman S (2003) Critical evaluation of the safety of Cimicifuga racemosa in menopause symptom relief, Menopause, 10.1097/01.GME.0000056039.51813.21, 10:4, (299-313), Online publication date: 1-Jul-2003. Johnson F (2002) How many food additives are rodent carcinogens?, Environmental and Molecular Mutagenesis, 10.1002/em.10037, 39:1, (69-80), . Claxton L, Hughes T and Chung K (2001) Using base-specific Salmonella tester strains to characterize the types of mutation induced by benzidine and benzidine congeners after reductive metabolism, Food and Chemical Toxicology, 10.1016/S0278-6915(01)00072-2, 39:12, (1253-1261), Online publication date: 1-Dec-2001. Johnson F and Snell M (2009) Short-Term Tests Are Unable to Distinguish Between Human Carcinogens and Noncarcinogens, Cancer Investigation, 10.3109/07357908609018456, 4:3, (271-280), Online publication date: 1-Jan-1986. Hancock R, Gerritsen N and Meadows H (2009) Effects of chemical carcinogens on bacteria and yeast: A review, Journal of Toxicology and Environmental Health, 10.1080/15287398109530005, 7:3-4, (607-642), Online publication date: 1-Mar-1981. Pashin Y and Bakhitova L (2018) Mutagenic and carcinogenic properties of polycyclic aromatic hydrocarbons., Environmental Health Perspectives, 30, (185-189), Online publication date: 1-Jun-1979. Hayden J (1977) Considerations in applying to man the results of drug effects observed in laboratory animals, The Journal of the American Dental Association, 10.14219/jada.archive.1977.0524, 95:4, (777-786), Online publication date: 1-Oct-1977. Bardoděj Z (1976) Metabolic studies and the evaluation of genetic risk from the viewpoint of industrial toxicology, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 10.1016/0027-5107(76)90069-5, 41:1, (7-14), Online publication date: 1-Nov-1976. Macgregor J and Sacks L (1976) The sporulation system of Bacillus subtilis as the basis of a multi-gene mutagen screening test, Mutation Research/Environmental Mutagenesis and Related Subjects, 10.1016/0165-1161(76)90151-5, 38:4, (271-285), Online publication date: 1-Aug-1976. Nichols W (2018) Significance of various type chromosome aberrations for man., Environmental Health Perspectives, 6, (179-183), Online publication date: 1-Dec-1973. Xu X, Watt D and Liu C (2015) Multifaceted roles for thymine DNA glycosylase in embryonic development and human carcinogenesis, Acta Biochimica et Biophysica Sinica, 10.1093/abbs/gmv083, (gmv083) Vol. 6December 1973Metrics About Article Metrics Publication History Originally published1 December 1973Published in print1 December 1973 Financial disclosuresPDF download License information EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. 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