Viral Infections and Lower Urinary Tract Symptoms in the Third National Health and Nutrition Examination Survey
2007; Lippincott Williams & Wilkins; Volume: 178; Issue: 5 Linguagem: Inglês
10.1016/j.juro.2007.06.041
ISSN1527-3792
AutoresSiobhan Sutcliffe, Sabine Rohrmann, Edward L. Giovannucci, Kenrad E. Nelson, Angelo M. De Marzo, William B. Isaacs, William G. Nelson, Elizabeth A. Platz,
Tópico(s)Urinary Tract Infections Management
ResumoNo AccessJournal of UrologyInvestigative urology1 Nov 2007Viral Infections and Lower Urinary Tract Symptoms in the Third National Health and Nutrition Examination Survey Siobhan Sutcliffe, Sabine Rohrmann, Edward Giovannucci, Kenrad E. Nelson, Angelo M. De Marzo, William B. Isaacs, William G. Nelson, and Elizabeth A. Platz Siobhan SutcliffeSiobhan Sutcliffe Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, The Johns Hopkins Medical Institutions, Baltimore, Maryland More articles by this author , Sabine RohrmannSabine Rohrmann Department of Clinical Epidemiology, German Cancer Research Centre, Heidelberg, Germany More articles by this author , Edward GiovannucciEdward Giovannucci Departments of Nutrition and Epidemiology, Harvard School of Public Health and Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts More articles by this author , Kenrad E. NelsonKenrad E. Nelson Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, The Johns Hopkins Medical Institutions, Baltimore, Maryland More articles by this author , Angelo M. De MarzoAngelo M. De Marzo James Buchanan Brady Urological Institute and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland More articles by this author , William B. IsaacsWilliam B. Isaacs James Buchanan Brady Urological Institute and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland More articles by this author , William G. NelsonWilliam G. Nelson James Buchanan Brady Urological Institute and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland Department of Oncology and Pharmacology, The Johns Hopkins Medical Institutions, Baltimore, Maryland Financial interest and/or other relationship with ProQuest Investments, Cell Genesys, Abbott, GlaxoSmithKline and Oncomethylome Sciences. More articles by this author , and Elizabeth A. PlatzElizabeth A. Platz Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, The Johns Hopkins Medical Institutions, Baltimore, Maryland James Buchanan Brady Urological Institute and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2007.06.041AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Previous epidemiological studies described suggestive positive associations between sexually transmitted infections, particularly gonorrhea and human immunodeficiency virus infection, and lower urinary tract symptoms. To our knowledge no groups have investigated other infections, such as human papillomavirus type 16, herpes simplex virus type 2, cytomegalovirus, human herpesvirus type 8, herpes simplex type 1, and hepatitis B and C virus infection, in relation to lower urinary tract symptoms. Therefore, we examined each of these associations in the Third National Health and Nutrition Examination Survey. Materials and Methods: The Third National Health and Nutrition Examination Survey is a representative, cross-sectional survey of the population in the United States that was done between 1988 and 1994. Each participant provided a blood sample and completed a computer assisted interview including questions on lower urinary tract symptoms (nocturia, incomplete emptying, hesitancy and weak stream). Blood samples were tested for IgG antibodies against each virus. Results: In younger men (ages 30 to 49 years) positive associations were observed between cytomegalovirus, human herpesvirus type 8, herpes simplex virus type 1, and hepatitis B and C virus antibody seropositivity, and lower urinary tract symptoms. In 50 to 59-year-old men positive associations were observed between human papillomavirus type 16, herpes simplex virus type 2, cytomegalovirus, human herpesvirus type 8 and hepatitis C virus antibody seropositivity and lower urinary tract symptoms. In men 60 years or older only a slight, nonsignificant positive association was observed between cytomegalovirus antibody seropositivity and lower urinary tract symptoms. Conclusions: In this cross-sectional survey of American men suggestive positive associations were observed between several viral infections and lower urinary tract symptoms, primarily in 30 to 59-year-old men. These findings provide interesting hypotheses and preliminary evidence for future etiological studies of infections and lower urinary tract symptoms. References 1 : The epidemiology of benign prostatic hyperplasia: a study in Greece. BJU Int1999; 84: 286. Google Scholar 2 : Risk factors for lower urinary tract symptoms in a population-based sample of African-American men. Am J Epidemiol2003; 157: 906. Google Scholar 3 : Sexually transmitted infections, prostatitis, ejaculation frequency, and the odds of lower urinary tract symptoms. Am J Epidemiol2005; 162: 898. Google Scholar 4 : Penis and urethra. In: Urology. Edited by . Philadelphia: WB Saunders Co1970: 544. Google Scholar 5 : Micturition disturbances and human immunodeficiency virus infection. J Urol1996; 156: 157. Link, Google Scholar 6 : Crystalluria and urinary tract abnormalities associated with indinavir. Ann Intern Med1997; 127: 119. Crossref, Medline, Google Scholar 7 : Sexual behavior and evidence for an infectious cause of prostate cancer. Epidemiol Rev2001; 23: 144. Google Scholar 8 : Elevated seroprevalence of human herpesvirus 8 among men with prostate cancer. J Infect Dis2004; 189: 15. Google Scholar 9 : Herpes simplex viruses 1 and 2. In: Viral Infections of Humans: Epidemiology and Control. Edited by . New York: Plenum Publishing Corporation1997: 419. Google Scholar 10 : Sexually Transmitted Diseases. New York: McGraw-Hill Co1999. Google Scholar 11 NHANES III Data Files. National Center for Disease Control, Centers for Disease Control. Available at: http://www.cdc.gov/nchs/about/major/nhanes/nh3data.htm. Accessed April 19, 2007. Google Scholar 12 : Seroprevalence of human papillomavirus type 16 infection in the United States. J Infect Dis2002; 186: 1396. Google Scholar 13 : Herpes simplex virus type 2 in the United States, 1976 to 1994. N Engl J Med1997; 337: 1105. Google Scholar 14 : National seroprevalence and trends in herpes simplex virus type 1 in the United States, 1976–1994. Sex Transmit Dis2004; 31: 753. Google Scholar 15 : Incidence of hepatitis B virus infection in the United States, 1976–1994: estimates from the National Health and Nutrition Examination Surveys. J Infect Dis1998; 178: 954. Google Scholar 16 : The prevalence of hepatitis C virus infection in the United States, 1988 through 1994. N Engl J Med1999; 341: 556. Google Scholar 17 : Platelet derived growth factor (PDGF), androgens and inflammation: possible etiologic factors in the development of prostatic hyperplasia. J Urol1993; 149: 1586. Abstract, Google Scholar 18 : Sex-hormone-induced inflammation and fibromuscular proliferation in the rat lateral prostate. Prostate1988; 12: 271. Google Scholar 19 : Hepatitis C virus infection and incident type 2 diabetes. Hepatology2003; 38: 50. Google Scholar 20 : Multicenter quality control for the detection of hepatitis C virus RNA in seminal plasma specimens. J Clin Microbiol2003; 41: 789. Google Scholar © 2007 by American Urological AssociationFiguresReferencesRelatedDetails Volume 178Issue 5November 2007Page: 2181-2185 Advertisement Copyright & Permissions© 2007 by American Urological AssociationKeywordsprostatic hyperplasiasexually transmitted diseases, viralviral diseasesprostateprostatismMetricsAuthor Information Siobhan Sutcliffe Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, The Johns Hopkins Medical Institutions, Baltimore, Maryland More articles by this author Sabine Rohrmann Department of Clinical Epidemiology, German Cancer Research Centre, Heidelberg, Germany More articles by this author Edward Giovannucci Departments of Nutrition and Epidemiology, Harvard School of Public Health and Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts More articles by this author Kenrad E. Nelson Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, The Johns Hopkins Medical Institutions, Baltimore, Maryland More articles by this author Angelo M. De Marzo James Buchanan Brady Urological Institute and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland More articles by this author William B. Isaacs James Buchanan Brady Urological Institute and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland More articles by this author William G. Nelson James Buchanan Brady Urological Institute and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland Department of Oncology and Pharmacology, The Johns Hopkins Medical Institutions, Baltimore, Maryland Financial interest and/or other relationship with ProQuest Investments, Cell Genesys, Abbott, GlaxoSmithKline and Oncomethylome Sciences. More articles by this author Elizabeth A. Platz Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, The Johns Hopkins Medical Institutions, Baltimore, Maryland James Buchanan Brady Urological Institute and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland More articles by this author Expand All Advertisement PDF downloadLoading ...
Referência(s)