Portal de Periódicos da CAPES

Artigo Produção Nacional Revisado por pares

BIBTEX RIS

Comparative study of cystatin C and serum creatinine in the estimative of glomerular filtration rate in children

2008; Elsevier BV; Volume: 391; Issue: 1-2 Linguagem: Inglês

10.1016/j.cca.2008.02.004

1873-3492

Vânia Feijó Cordeiro, Diana Célia Sousa Nunes‐Pinheiro, Geraldo Bezerra da Silva, José Wellington Oliveira Lima, Rosa Maria Salani Mota, Alexandre Braga Libório, Elizabeth De Francesco Daher,

Acute Kidney Injury Research

To compare estimated glomerular filtration rate (GFR) by Schwartz formula and cystatin C-derived formula in a large population of children with a large spectrum of renal disease. Serum creatinine, cystatin C and estimated GFR were determined in 273 children, 254 with renal disease, and a mean age of 10.0 ± 4.4 y. Nineteen children were used as control, with a mean age of 8.5 ± 4.2 y. The children had nephrotic syndrome (16.5%), glomerulonephritis (11.4%), neurogenic bladder (11.4%), hydronephrosis (9.8%), asymptomatic hematuria (11%), chronic renal disease (5.9%) and other diseases (11%). Cystatin C, creatinine, Schwartz estimated GFR and cystatin C estimated GFR (mean ± SD) were 1.30 ± 1.03 mg/dl, 0.82 ± 1.20 mg/l, 143 ± 72 ml/min/1.73 m2 and 88 ± 36 ml/min/1.73 m2, respectively. Although GFR estimated by creatinine and cystatin C had a significant correlation, the Bland–Altman analysis showed greater differences between GFR estimated by the 2 methods, with a mean difference of 50 ml/min. Besides, > 50% of the patients with a reduced cystatin C estimated GFR had a normal GFR when analyzed by the Schwartz formula. Our data shows that cystatin C-based GFR is more sensitive than previous study had demonstrated. It is important to perform studies in specific populations to determine the variability in GFR measurements.