Identification of Putative Human T Cell Receptor δ Complementary DNA Clones
1987; American Association for the Advancement of Science; Volume: 238; Issue: 4827 Linguagem: Inglês
10.1126/science.3499667
ISSN1095-9203
AutoresShingo Hata, Michael B. Brenner, Michael S. Krangel,
Tópico(s)Monoclonal and Polyclonal Antibodies Research
ResumoA novel T cell receptor (TCR) subunit termed TCR δ, associated with TCR γ and CD3 polypeptides, was recently found on a subpopulation of human T lymphocytes. T cell-specific complementary DNA clones present in a human TCR γδ T cell complementary DNA library were obtained and characterized in order to identify candidate clones encoding TCR δ. One cross-hybridizing group of clones detected transcripts that are expressed in lymphocytes bearing TCR γδ but not in other T lymphocytes and are encoded by genes that are rearranged in TCR γδ lymphocytes but deleted in other T lymphocytes. Their sequences indicate homology to the variable, joining, and constant elements of other TCR and immunoglobulin genes. These characteristics, as well as the immunochemical data presented in a companion paper, are strong evidence that the complementary DNA clones encode TCR δ.
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