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Lithothamnion muelleri Treatment Ameliorates Inflammatory and Hypernociceptive Responses in Antigen-Induced Arthritis in Mice

2015; Public Library of Science; Volume: 10; Issue: 3 Linguagem: Inglês

10.1371/journal.pone.0118356

ISSN

1932-6203

Autores

Vivian Vasconcelos Costa, Flávio A. Amaral, Fernanda M. Coelho, Celso Martins Queiroz‐Junior, Bruna G. Malagoli, José Hugo de Sousa Gomes, Fernando Lopes, Kátia D. Silveira, Daniela Sachs, Caio T. Fagundes, Lívia D. Tavares, Vanessa Pinho, Tarcı́lia Aparecida Silva, Mauro Martins Teixeira, Fernão Castro Braga, Danielle G. Souza,

Tópico(s)

Sphingolipid Metabolism and Signaling

Resumo

Rheumatoid Arthritis (RA) is a chronic disease characterized by persistent inflammation and pain. Alternative therapies to reduce these symptoms are needed. Marine algae are valuable sources of diverse bioactive compounds. Lithothamnion muelleri (Hapalidiaceae) is a marine algae with anti-inflammatory, antitumor, and immunomodulatory properties. Here, we investigated the potential anti-inflammatory and analgesic activities of L. muelleri in a murine model of antigen-induced arthritis (AIA) in mice. Our results demonstrate that treatment with L. muelleri prevented inflammation and hypernociception in arthritic mice. Mechanistically, the crude extract and the polysaccharide-rich fractions of L. muelleri may act impairing the production of the chemokines CXCL1 and CXCL2, and consequently inhibit neutrophil influx to the knee joint by dampening the adhesion step of leukocyte recruitment in the knee microvessels. Altogether our results suggest that treatment with L.muelleri has a potential therapeutic application in arthritis treatment.

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