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Pneumocystis Jiroveci (Carinii) Pneumonia Following Initiation of Infliximab and Azathioprine Therapy in a Patient With Crohnʼs Disease

2004; Oxford University Press; Volume: 10; Issue: 4 Linguagem: Inglês

10.1097/00054725-200407000-00017

1536-4844

Mimouna Seddik, Hugues Meliez, D. Séguy, N. Viget, Antoine Cortot, Jean Frédéric Colombel,

Immunodeficiency and Autoimmune Disorders

Anti-TNFα therapy is an effective treatment of Crohn's disease. There is an increased risk of infection, including atypical infection associated in infliximab treated patients. We report a case of a young man who developed Pneumocystis jiroveci pneumonia shortly after starting therapy with infliximab. Thus, although rare, prophylaxis against Pneumocystis jiroveci pneumonia might be considered when starting a treatment with infliximab, especially in patients receiving concomitant immunosuppressive agents.